Preparation of low cost SERS-substrates for virus characterization
Keywords:
SERS, Virus, Influenza, Coffe ring effect, NanoparticlesAbstract
Raman spectroscopy is a technique that allows the characterization and detection of a wide range of molecules. The characterization of biomolecules and viruses has been a novel application in the last decades. A relevant problem for applying this technique is the low intensity of the Raman signal and the low concentration of the analyte, which makes the identification of molecules and viruses quite difficult. An alternative to overcome this problem is the use of surface- enhanced Raman spectroscopy (SERS). This involves the use of SERS-substrates that generally are very expensive and can only be used once. In this work, we report the preliminary results of virus detection by SERS using low-cost homemade substrates and commercially available substrates. Characteristic Raman peaks associated with the influenza virus were detected. The results obtained with the homemade SERS-substrates are comparable to the obtained by using the comercial ones.
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