Acute and sub-acute oral toxicity study of the ethanolic extract of leaves from Hamelia patens (Rubiceae) in mice
Keywords:
Hamelia patens, Acute toxicity, Subacute toxicityAbstract
The ethanol extract of leaves from Hamelia patens was evaluated for acute and sub-acute oral toxicity. The single oral doses of the ethanol extract at 5, 50, 300, and 2000 mg/kg body weight did not produce mortality or significant changes in the general behaviors. In the sub-acute toxicity study, the ethanol extract was administrated orally at a dose of 2000 mg/km/day for 28 days. The results show a CL50 up from 2000 mg/kg, which is indicative of safe use for the human being because does not represent serious alterations in the state of health of the experimental animals
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