Sub-chronic toxicity and in vivo analgesic activity of the chlorophormal extract of Calea urticifolia (Juanislama) leaves
Keywords:
Calea urticifolia, Sub-chronic toxicity, AnalgesiaAbstract
Introduction: The population uses medicinal plants indiscriminately to treat diseases, with the believe that they are safe and lack adverse effects. Objective: To determine the in vivo toxicological and analgesic effect of the chloroform extract of Calea urticifolia leaves. Methodology: The toxicological study was performed using a 90- day sub-chronic toxicity test in NIH mice, at repeated and continuous doses. . Blood biochemistry, hematology and histopathological examination of organs were performed. The analgesic activity was evaluated in vivo using a model of abdominal contortions. Results: The administration of the plant extract caused the appearance of clinical signs of toxicity, alterations in hematic parameters and blood biochemistry, as well as histological alterations in some of organs. The analgesic activity at 100 mg/kg was similar to the Indomethacin drug. Conclusion: Despite the proven analgesic activity, according to the observed toxicological effects in this study, the prolonged use of Calea urticifolia leaves is not recommended for the treatment of diseases
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