Late Relapse of Embryonal Rhabdomyosarcoma, Botryoid Variant, of the Vagina
Keywords:
Chemotherapy, Hormone receptors, Menarche, RhabdomyosarcomaAbstract
We report on two very similar cases of vaginal embryonal RMS, botryoid variant that relapsed 9 and 10 years after initial diagnosis, a few months after the menarche in both cases. A possible causal association with estrogen hormones is hypothesized, particularly for the second case described, in which estrogen receptors were negative in the primary tumor specimen and positive in the relapsing tumor specimen. Pediatr Blood Cancer 2008; 51:140–141.
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Wexler LH, Meyer WH, Helman LJ. Rhabdomyosarcoma and the undifferentiated sarcomas. In: Pizzo PA, Poplack DG, editors. Principles and practice of pediatric oncology, 5th edition. Philadelphia, PA: Lippinco--tt Williams & Wilkins; 2006. pp. 971–1001.
Pappo AS, Anderson JR, Crist WM, et al. Survival after relapse in children and adolescentswith rhabdomyosarcoma:Areport from the Intergroup Rhabdomyosarcoma Study Group. J Clin Oncol 1999; 17:3487–3493.
Sung L, Anderson JR, Donaldson SS, et al. Late events occurring five years or more after successful therapy for childhood rhabdomyosarcoma: A report from the Soft Tissue Sarcoma Committee of the Children’s Oncology Group. Eur J Cancer 2004; 40:1878–1885.
Mazzoleni S, Bisogno G, Garaventa A, et al. Outcomes and prognostic factors after recurrence in children and adolescents with nonmetastatic rhabdomyosarcoma. Cancer 2005; 104:183–190.
Leuschner I, Harms D, Mattke A, et al. Rhabdomyosarcoma of the urinary bladder and vagina.Aclinicopathologic study with emphasis on recurrent disease: A report from the Kiel Pediatric Tumor Registry and the German CWS Study. Am J Surg Pathol 2001; 25: 856–864?
Diller L, Sexsmith E, Gottlieb A, et al. Germline p53 mutations are frequently detected in young children with rhabdomyosarcoma. J Clin Invest 1995; 95:1606–1611.
Gripp KW, Scott CI, Jr., Nicholson L, et al. Five additional Costello syndrome patients with rhabdomyosarcoma: Proposal for a tumor screening protocol. Am J Med Genet 2002; 108:80–87.
Ferrari A, Bisogno G, Macaluso A, et al. Soft-tissue sarcomas in children and adolescents with neurofibromatosis type 1. Cancer 2007; 109:1406–1412.
Zacharin M, Waters K, Chow CW, et al. Recurrent rhabdomyosarcoma after 25 years: A possible association with estrogens and progestogen therapy. J Pediatr Haematol Oncol 1997; 19:477–481.
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